PEGylation相关论文
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PEGylated multi-walled carbon nanotubes as a platform for blood pool and tumor magnetic resonance im
Magnetic resonance (MR) imaging has been extensively used as a powerful imaging technique in clinical diagnosis, because......
Polycationic gene delivery system was widely used for cancer therapy.Polycations with high positive potentials exhibited......
Effects of Temperature and PEG Density on the Translocation of PEGylated Nanoparticles across Asymme
Internalization of nanoparticles(NPs)by membranes is critical for the applications of nano-drugs in diagnosis and treatm......
Thiol "click" chemistry is an attractive tool for postpolymerization modification of thiolmers or thiol containing sub......
Encapsulation of doxorubicin within lactobionic acid-modified multifunctional poly(amidoamine) dendr
Current anticancer drugs used in the clinic suffer trom problems such as poor water solubility,rapid clearance,and nonsp......
To achieve highly effective drug accumulation at the tumor site,conventional nano-sized delivery systems most frequently......
PO0745 Endoglin single-chain antibody conjugated PEGylated immunoliposomes enhances anti-tumor capac
Objective Tumor can not be completely removed due to the absence of immune storm against tumor.The porcine α 1,3 galact......
PEGylation facilitates oral absorption of intact lipid-based nanoparticlesby slowing down in vivo li
PEGylation has been widely applied to improve the oral absorption of proteins and peptides as well as drug delivery syst......
Intein-mediated site-specific synthesis of activatableprotein delivery system:turning PEG dilemma in
Clinical translation of protein toxins for cancer therapy is restrained by the short half-life and poor cellular uptake ......
Protein PEGylation(attaching PEG chains to proteins)has been widely used in pharmaceuticals and nanotechnology.Although ......
目的探讨聚乙二醇化脂质体多柔比星（PLD）致晚期乳腺癌患者速发型超敏反应与血浆抗聚乙二醇（PEG）抗体的相关性。方法研究设计为前瞻性非......
Although the antitumor drug cabazitaxel shows great therapeutic potential,its high toxicity and poor water solubility li......
目的:考察mPEG-SC与重组猪尿酸氧化酶(recombinant porcine urate oxidase,rPUOX)摩尔比值,碳酸缓冲液pH值和浓度,以及酶浓度对rPU......
基因治疗是治疗多种疾病的一种强有力的手段。有效递送目的基因至病灶治疗部位是基因治疗成功的关键。目前常用的基因载体大多为阳......
研究mPEG-ALD修饰CPU-HM的反应条件并对修饰产物的体内药效进行初步筛选。采用正交试验法,利用HPLC的面积归一化法检测各修饰条件......
All atomistic molecular dynamics simulations were performed on poly(amidoamine)(PAMAM) dendrimers that compound non-cova......
,Anti-tumor activity and immunological modification of ribosome-inactivating protein (RIP) from Momo
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A hybrid of organic/inorganic system,hollow mesoporous silica nanoparticles functionalized with poly(ethylene glycol),wa......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的研究氧化石墨烯(GO)PEG化前、后对L929细胞毒性的影响。方法将羧基化后的GO分子通过酰胺键与双端氨基聚乙二醇4000(NH2-PEG400......
Comparisons ofbiophysical properties andbioactivities ofmono-PEGylated endostatin andan endostatin a
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 研究化学修饰剂聚乙二醇(PEG)对德国小蠊(蟑螂)重组变应原rBla g 2变应原性的影响.方法 rBla g2在大肠肝菌中表达后,采用Ni+......
Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol (PEG) were prepared via PE......
为获得可溶性聚乙二醇（PEG）化紫杉醇,制备了不同相对分子质量的PEG氨基酸衍生物,并通过氨基酸连接臂将PEG连接到紫杉醇上,获得了具有......
为了研究聚乙二醇对PEG化rhEPO热稳定性和生物学活性的影响,用酶学方法切除rhEPO和 PEG-rhEPO分子中的N-连接糖基,研究酶切产物在3......
提出了一种新型聚乙二醇（PEG）修饰剂的合成方法。首先以两种ω-氨基酸和单甲氧基PEG为主要原料,经连接、纯化和水解等步骤,得到末端......
目的：为了降低尿酸酶的免疫原性并提高其稳定性，利用PEG修饰剂对尿酸酶进行修饰，以期获得性质更优的治疗痛风的药物。方法：用相对分子......
聚乙二醇化技术又称为PEG修饰技术，是目前分子变构化学中最重要的技术之一。经过近几十年的发展，PEG化技术不仅在蛋白质类药物的开发......
以溶菌酶为模型蛋白,通过活性测定比较了PEG修饰前后溶菌酶复性动力学的差异,同时利用圆二色谱、色氨酸荧光谱等方法比较了PEG修饰......
基于荧光素酶报告基因法和本实验室前期构建的CHO-GLP-1R-CRE-Luc＋检测模型细胞株,建立并优化了长效降糖多肽——聚乙二醇化Exendin......
目的：评价聚乙二醇化重组人粒细胞刺激因子（PEG～rhG—CSF）用于肿瘤患者的安全性和耐受性，初步观察化疗后PEG—rhG—CSF升高外周血中性粒......
采用分子量为20kD的单甲氧基聚乙二醇丙醛（mPEG-ALD）修饰重组人干扰素α-2b（IFNα-2b），建立了修饰反应及分离纯化工艺。考察了修饰反应......
20世纪70年代Davis等[1]的开拓性工作,使得聚乙二醇化的蛋白质和多肽在生物医学和生物技术等诸多领域得到越来越广泛的应用.蛋白质......
建立了HPLC法检测聚乙二醇化天花粉蛋白注射液中天花粉蛋白的含量。采用硅胶基TSK-G3000SW凝胶柱，0．02mol／L磷酸二氢钠溶液-0．15mol／L氯......
为提高纤溶酶的临床适用性，采用4种针对氨基修饰的mPEG试剂——mPEG—SPA5K、mPEG—SMB5K、mPEG—ButyrALD5K和mPEG2-NHS40K修饰蛇......
目的合成人甲状旁腺素(1-34)[hPTH(1-34)]并进行聚乙二醇化修饰.方法应用固相多肽合成方法合成并经高效液相色谱纯化得hPTH(1-34),......
目的通过对人血清白蛋白（HSA）进行聚乙二醇（PEG）修饰合成PEG化HSA（PEG-HSA）,以期减少HSA的血管透过率,延长其血管保留时间。方法采用氰尿......
合成了一种新型的蛋白质及多肽胍基的PEG化试剂,其化学本质为mPEG单取代的乙酰丙酮,用于改造蛋白质及多肽的溶解性、稳定性、免疫......
背景与目的：重组人粒细胞集落刺激因子（rhG—CSF）是防治肿瘤化放疗引起的中性粒细胞减少症的有效药物，但半衰期短，需每日给药。聚乙二醇......
【正】Objective:To investigate the characteristics of PEGylated mucin and its potential usage. Methods:Mucin was extract......
【正】Objective:To investigate the characteristics of PEGylated mucin and its potential usage. Methods:Mucin was extract......
临床用重组人促红细胞生成素（rhEpo）是中国仓鼠卵巢细胞（Chinese hamster ovary cell,CHO）表达的糖蛋白,糖基对稳定蛋白的结构和生物活......
通过细胞集落实验和体外活性实验，对聚乙二醇化重组人粒细胞集落刺激因子（PEGrhG—CSF）和重组人粒细胞集落刺激因子（rhG—CSF）的体外生......
